The road towards vaccine that prevent tumor formation
Raffaele Calogero / Federica Cavallo / Guido Forni
raffaele.calogero@unito.it
federica.cavallo@unito.it
guido.forni@unito.it

 

Description
Selected publications

Sassano A, Lo Iacono M, Antico G, Jordan A, Uddin S, Calogero RA, Platanias LC. Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins. Mol Cancer Ther. 2009;8:615-25

Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M,Burghart E, Forni G, Eils R, Fehm T, Riethmüller G, and Klein CA, Systemic spread is an early step in breast cancer, Cancer Cell 2008;13:58-68

Chiarle R, Martinengo C, Mastini C, Ambrogio C, D’Escamard V, Forni G, Inghirami G, The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination, Nature Med 2008;14:676-680

Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M, Lactoferrin, a Major Defense Protein of innate immunity, is a novel maturation factor for human dendritic cells, FASEB J 2008;22:2747-2757

Curcio C, Khan, AS, Amici A, Spadaro M, Quaglino E, Cavallo F, Forni G, Draghia-Akli R. DNA immunization using constant-current electroporation affords long-term protection from autochthonous mammary carcinomas in cancer prone transgenic mice, Cancer Gene Ther 2008;15:108-114

Calogero RA, Quaglino E, Saviozzi S, Forni G, Cavallo F, Oncoantigens as anti-tumor vaccination targets: The chance of a lucky strike?, Cancer Immunol Immunother, 2008;57:1685-1694

Rolla S, Marchini C, Malinarich S, Quaglino E, Lanzardo S, Montani M, Angeletti M, Ramadori G, Forni G, Cavallo F, Amici A, Protective immunity against neu+ carcinomas elicited by electroporation of plasmids coding for decreasing fragments of rat neu extracellular domain, Human Gene Ther 2008;19:229-240

Della Beffa C, Cordero F, Calogero RA. Dissecting an alternative splicing analysis workflow for GeneChip Exon 1.0 ST Affymetrix arrays. BMC Genomics. 2008;28;9:571

Cavallo F, Calogero RA, Forni G. Are oncoantigens suitable targets for anti-tumour therapy? Nat Rev Cancer. 2007;7:707-13.

Calogero RA, Cordero F, Forni G, Cavallo F, Inflammatory component of mammary carcinogenesis in Erbb2 transgenic mice, Breast Cancer Res 2007;9:211-217

Sanges R, Cordero F, Calogero RA. oneChannelGUI: a graphical interface to Bioconductor tools, designed for life scientists who are not familiar with R language. Bioinformatics. 2007;23:3406-8

Bosotti R, Locatelli G, Healy S, Scacheri E, Sartori L, Mercurio C, Calogero R, Isacchi A. Cross platform microarray analysis for robust identification of differentially expressed genes. BMC Bioinformatics. 2007;8s1:S5

Curcio C, Pannellini T, Lanzardo S, Forni G, Musiani P, Anton I. WIP null mice display a progressive immunological disorder that resembles Wiskott-Aldrich syndrome. J Pathol 2007; 211:67-75

Spadaro M, Curcio C, Varadhachary A, Cavallo F, Engelmayer J, Blezinger P, Pericle F, Forni G, Requirement for IFN-g, CD8+ T lymphocytes and NKT cells in Talactoferrin-induced inhibition of neu+ tumors, Cancer Res 2007;67:6425-6432

Holmgren L, Ambrosino E, Birot O, Tullus C, Veitonmäki N, Levchenko T, Carlson LM, Musiani P, Iezzi M, Curcio C, Forni G, Cavallo F, Kiessling R. A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth. Proc Natl Acad Sci U S A. 2006;103:9208-13

Lollini PL, Cavallo F, Nanni P, Forni G. Vaccines for tumour prevention. Nat Rev Cancer. 2006;6:204-16

Cavallo F, Offringa R, van der Burg SH, Forni G, Melief CJ. Vaccination for treatment and prevention of cancer in animal models. Adv Immunol. 2006;90:175-213.

Ambrosino E, Spadaro M, Iezzi M, Curcio C, Forni G, Musiani P, Wei WZ, Cavallo F. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 2006;66:7734-7740

Rolla S, Nicolo C, Malinarich S, Orsini M, Forni G, Cavallo F, Ria F. Distinct and non-overlapping T cell receptor repertoires expanded by DNA vaccination in wild-type and HER-2 transgenic BALB/c mice. J Immunol 2006;177:7626-7633

Cavallo F, Astolfi A, Iezzi M, Cordero F, Lollini P-L, Forni G, Calogero R, An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention, BMC Bionformatics 2005;6S4:1-9

Spadaro M, Ambrosino E, Iezzi M, Di Carlo E, Sacchetti P, Curcio C, Amici A, Wei WZ, Musiani P, Lollini PL, Forni G, F Cavallo, Cure of mammary carcinomas in Her-2 transgenic mice through sequential stimulation of innate (neo-adjuvant il12) and adaptive (DNA Vaccine Electroporation) immunity, Clin Cancer Res 2005;11:1941-1952

Astolfi A, Landuzzi L, Nicoletti G, De Giovanni, Croci S, Paladini A, Ferrini S, Iezzi M, Musiani P, Cavallo F, Forni G, Nanni P, Lollini P-L, Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma, Am J Pathol 2005;166:1205-1216

Quaglino E, Rolla S, Iezzi M, Spadaro M, Musiani P, De Giovanni C, Lollini PL, Lanzardo S, Forni G, Sanges R, Crispi S, De Luca P, Calogero R, Cavallo F. Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions.J Clin Invest. 2004;113:709-717

 

 

Unit members

 

Arigoni Maddalena Postdoctoral fellow  
Bandini
Silvio Ph.D. student  
Barutello Giuseppina Graduate student g.barutello@libero.it 
Bolli Elisabetta Postdoctoral fellow bettabolli@hotmail.com 
Cojoca Rodica Postdoctoral fellow  rodica73@libero.it 
Cordero Francesca Postdoctoral fellow fcordero@di.unito.it 
Della Beffa Cristina Ph.D. student cristina.dellabeffa@gmail.com 
Lanzardo Stefania Postdoctoral fellow  stefania.lanzardo@unito.it 
Macagno Marco Ph.D. student marco.macagno@unito.it 
Merighi Irene Lab technician irene.merighi@unito.it 
Montone Monica Graduate student monica86m@gmail.com 
Pinto Hedwige Ph.D. student hedwige.pinto@unito.it
Prestigio   Simone Graduate student simoneprestigio@virgilio.it 
Quaglino Elena Postdoctoral fellow elena.quaglino@unito.it 
Saviozzi Silvia Lab technician silvia.saviozzi@unito.it 
Spadaro Michela Postdoctoral fellow

 

 

 

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