Molecular mechanisms underlying the pathogenesis of cerebral cavernous malformations
Saverio Francesco Retta
francesco.retta@unito.it

 

Description

Identification and characterization of novel molecules and mechanisms involved in the regulation of CCM gene functions.

Production of animal models of CCM disease.

 

 

Selected publications

Francalanci F., Avolio M., De Luca E., Longo D., Menchise V., Guazzi P., Sgrò F., Marino M., Goitre L., Balzac F., Trabalzini L., Retta S. F. (2009). Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis. Experimental Cell Research, 315: 285-303.

Vanni C., Visco V., Parodi A., Ottaviano C., Manazza A., Retta S.F., Varesio L., Mancini P., Torrisi M.R., Eva A. (2006). Inhibition of PI3K induces Rac activation and membrane ruffling in protoDbl expressing cells. Cell Cycle, 5: 2657-2665.

Retta S.F., Balzac F., Avolio M. (2006). Rap1: a turnabout for the crosstalk between cadherins and integrins. European Journal of Cell Biology, 85:283-293.

Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF. (2005). E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. Journal of Cell Science, 118 (20): 4765-4783.

Fournier HN, Dupé-Manet S, Bouvard D, Luton F, Degani S, Block MR, Retta SF, Albiges-Rizo C. (2005). Nuclear translocation of ICAP-1 stimulates cellular proliferation. Molecular Biology of the Cell, 16: 1859-1871.

Retta S.F., Avolio M., Francalanci F., Procida S., Balzac F., Degani S., Tarone G., Silengo L. (2004). Identification of Krit1B: a Novel Alternative Splicing Isoform of Cerebral Cavernous Malformation Gene-1 (CCM1). Gene, 325: 63-78.

Arcucci A, Alaia V, Montagnani S, Pontarelli G, Retta SF, Tarone G, Gionti E. (2003). Altered expression of integrins in RSV-transformed chick epiphyseal chondrocytes. Biochimie, 85: 483-492.

Bouvard D, Vignoud L, Dupe-Manet S, Abed N, Fournier HN, Vincent-Monegat C, Retta SF, Fassler R, Block MR (2003). Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. Journal of Biological Chemistry, 278: 6567-6574.

 

 

Unit members

 

Balzac Fiorella Technician fiorella.balzac@unito.it
Francalanci Floriana PhD fellow floriana.francalanci@unito.it
Goitre Luca PhD fellow luca.goitre@unito.it
De Luca Elisa PhD fellow elisa.deluca@unito.it
Marino Marco PhD fellow marco.marino@unito.it
Sgrò Francesco Telethon fellow francesco.sgro@unito.it

 

 

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