Molecular mechanisms of cardiac hypertrophy and protection against heart failure
Mara Brancaccio / Guido Tarone
mara.brancaccio@unito.it
guido.tarone@unito.it

 

Description

 

 

 

 

Selected publications

Mara Brancaccio

Anastasi, G., Amato, A., Tarone, G., Vita, G., Monici, M. C., Magaudda, L., Brancaccio, M., Sidoti, A., Trimarchi, F., Favaloro, A., and Cutroneo, G. (2003). Distribution and localization of vinculin-talin-integrin system and dystrophin-glycoprotein complex in human skeletal muscle. Immunohistochemical study using confocal laser scanning microscopy. Cells Tissues Organs 175, 151-164.

Barberis, L., Wary, K. K., Fiucci, G., Liu, F., Hirsch, E., Brancaccio, M., Altruda, F., Tarone, G., and Giancotti, F. G. (2000). Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275, 36532-36540.

Brancaccio, M., Cabodi, S., Belkin, A. M., Collo, G., Koteliansky, V. E., Tomatis, D., Altruda, F., Silengo, L., and Tarone, G. (1998). Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun 5, 193-205.

Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., De Acetis, M., Vecchione, C., Marino, G., Altruda, F., et al. (2003a). Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9, 68-75.

Brancaccio, M., Guazzone, S., Menini, N., Sibona, E., Hirsch, E., De Andrea, M., Rocchi, M., Altruda, F., Tarone, G., and Silengo, L. (1999). Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem 274, 29282-29288.

Brancaccio, M., Hirsch, E., Notte, A., Selvetella, G., Lembo, G., and Tarone, G. (2006). Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res 70, 422-433.

Brancaccio, M., Menini, N., Bongioanni, D., Ferretti, R., De Acetis, M., Silengo, L., and Tarone, G. (2003b). Chp-1 and melusin, two CHORD containing proteins in vertebrates. FEBS Lett 551, 47-52.

Brancaccio, M., Turco, E., and Hirsch, E. (2009). Tissue-Specific KO of ECM Proteins. Methods Mol Biol 522, 1-36.

Brokat, S., Thomas, J., Herda, L. R., Knosalla, C., Pregla, R., Brancaccio, M., Accornero, F., Tarone, G., Hetzer, R., and Regitz-Zagrosek, V. (2007). Altered melusin expression in the hearts of aortic stenosis patients. Eur J Heart Fail 9, 568-573.

De Acetis, M., Notte, A., Accornero, F., Selvetella, G., Brancaccio, M., Vecchione, C., Sbroggio, M., Collino, F., Pacchioni, B., Lanfranchi, G., et al. (2005). Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 96, 1087-1094.

Degani, S., Balzac, F., Brancaccio, M., Guazzone, S., Retta, S. F., Silengo, L., Eva, A., and Tarone, G. (2002). The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. J Cell Biol 156, 377-387.

Hirsch, E., Barberis, L., Brancaccio, M., Azzolino, O., Xu, D., Kyriakis, J. M., Silengo, L., Giancotti, F. G., Tarone, G., Fassler, R., and Altruda, F. (2002). Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol 157, 481-492.

Hirsch, E., Brancaccio, M., and Altruda, F. (2000). Tissue-specific KO of ECM proteins. Methods Mol Biol 139, 147-178.

Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S., Russo, G., Azzolino, O., Rybalkin, S. D., et al. (2004). PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118, 375-387.

Sbroggio, M., Ferretti, R., Percivalle, E., Gutkowska, M., Zylicz, A., Michowski, W., Kuznicki, J., Accornero, F., Pacchioni, B., Lanfranchi, G., et al. (2008). The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett 582, 1788-1794.

Tarone, G., Hirsch, E., Brancaccio, M., De Acetis, M., Barberis, L., Balzac, F., Retta, S. F., Botta, C., Altruda, F., and Silengo, L. (2000). Integrin function and regulation in development. Int J Dev Biol 44, 725-731.

Vecchione, C., Patrucco, E., Marino, G., Barberis, L., Poulet, R., Aretini, A., Maffei, A., Gentile, M. T., Storto, M., Azzolino, O., et al. (2005). Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med 201, 1217-1228.

Volpe, G., Cignetti, A., Panuzzo, C., Kuka, M., Vitaggio, K., Brancaccio, M., Perrone, G., Rinaldi, M., Prato, G., Fava, M., et al. (2007). Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67, 5300-5307.

 


 

Guido Tarone

 

 

Unit members

 


Ferretti Roberta Post-doc roberta.ferretti@unito.it

Percivalle Elena Post-doc elena.percivalle@unito.it

Sbroggiò Mauro PhD student mauro.sbroggio@unito.it

Di Savino Augusta PhD student augusta.disavino@hotmail.it

Fusella Federica Student fedef28@yahoo.it 

Bertero Alessandro Student berteroale@hotmail.it 
copyright © 2009 MBC